A Guide to Buying Ultra-Low Temperature Freezers

Last Updated on 

January 22, 2025

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Excedr
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In labs where sensitive samples, reagents, and biological materials are handled, cold storage plays a critical role in preserving their integrity. Ultra-low temperature (ULT) freezers are essential for labs conducting advanced research, ensuring that vital samples—ranging from vaccines to DNA—are stored safely for long-term use.

The demand for ULT freezers continues to rise, fueled by growth in key areas like:

  • Funding for biomedical and life sciences research
  • Increasing need for vaccine storage and production
  • Organ donation and preservation
  • Advancements in genome and DNA research
  • Adoption of eco-friendly and energy-efficient technologies

With so many factors influencing the need for these freezers, finding the right one for your lab can feel overwhelming. This guide will help you navigate the available options, understand what ULT freezers are, and explore key considerations for making an informed purchase.

Ultra-Low Temperature Freezers—What Are They?

Ultra-low temperature (ULT) freezers, distinct from cryogenic freezers, are essential in any lab that requires long-term storage of sensitive biological samples. These freezers operate between -50°C and -86°C, providing a much colder environment than standard freezers.

ULT freezers are used to store a variety of materials, including:

  • Plasma
  • Stem cells
  • Bone marrow
  • Sperm
  • Vaccines
  • Flammable chemicals
  • Animal DNA

Given that many labs store samples worth hundreds of thousands of dollars, reliable cold storage is critical. But beyond reliability, factors like price, energy efficiency, storage capacity, noise levels, and physical space in the lab should also be considered. Poor storage conditions can lead to the loss of valuable samples, resulting in significant operational disruptions.

Pricing for ULT freezers depends on voltage, box capacity, and cubic footage, with costs ranging between $8,000 and $20,000. These figures can vary based on the manufacturer and whether the unit is new or used.

What Type of Ultra-Low Temp Freezer Is Right for Your Lab?

Choosing the right ULT freezer for your lab can be daunting, given the wide array of available options and features. ULT freezers come with different finishes, touchscreen interfaces, alarm systems, refrigeration cycles, and compressors.

To simplify your decision-making process, it’s helpful to start by understanding the most common types of ULT freezers:

Upright Freezers

Upright ULT freezers are similar to the upright models found in most restaurants or used for long term food storage. They are available in one door and two-door configurations, allowing you to choose the one that best fits your available lab space and workflow.

They are the ideal option when there isn’t a lot of available floor space, but there is plenty of room in the area to allow for the doors to open out. This is especially helpful for labs that utilize many shelves and overhead compartments along walls.

Some upright models offer an automatic defrost option. Many include built-in shelves and racks.

Chest Freezers

ULT chest freezers are similar to residential or commercial deep freezers. They take up more floor space but open up from the top, with the freezer door on top acting as a lid. Inside the freezer, you can place racks and boxes to make storage and organization easier.

Walk-in Freezers

A walk-in freezer is needed in rare situations where an extensive sample collection has to be maintained across a high number of individual ULT freezers. Walk-in freezers allow professionals to walk in and out on an as-needed basis to access the samples. With this approach, the staff is limited to the amount of time they can remain in the freezer.

Some standard operating procedures should be in place to ensure the safety of all professionals who must enter. Access to the freezers themselves should also be limited so the freezers can recover after being exposed to warmer air.

You can also find benchtop freezers designed to sit on a counter. If you don’t need a lot of storage space, you may also consider under-counter models.

Where Can I Find Ultra-Low Temp Freezers?

You have several options for sourcing ultra-low temperature freezers, including purchasing directly from ULT freezer manufacturers, exploring lab auctions, or opting to lease. Here are some well-known manufacturers that offer high-quality ULT freezers:

  • Eppendorf: Founded in Hamburg, Germany, Eppendorf specializes in laboratory equipment, including ULT freezers. Their freezers are known for reliability, and you can expect pricing to range from $12,000 to $21,000 depending on the model and specifications.
  • Thermo Fisher Scientific: A leader in the life sciences industry, Thermo Fisher provides a wide variety of ULT freezers, many of which are FDA approved. Prices typically fall between $12,000 and $18,000, though you may need to contact the company for a precise quote.
  • Nuaire: Since its founding in 1971, Nuaire has specialized in designing lab equipment for the healthcare sector, including ULT freezers. For pricing and model specifics, you’ll need to request a quote directly from their website.
  • PHCbi: PHCbi offers a range of high-performance ULT freezers with advanced features like energy-efficient refrigeration systems. These units are designed for minimal environmental impact. Pricing is available upon request from the manufacturer.
  • Haier Biomedical: Haier Biomedical manufactures a range of lab equipment, including ULT freezers designed for life sciences and biomedical research. Known for their innovative and energy-efficient designs, their pricing typically falls in the mid-range, but quotes can vary depending on specifications.
  • VWR (Part of Avantor): VWR provides ULT freezers along with a wide range of other lab supplies and equipment. Known for quality and competitive pricing, their freezers are available in various sizes and configurations. Pricing details are available upon request from VWR or Avantor.

Although we're biased, as a leasing company, it'd be remiss of us to point out that leasing ULT freezers is a cost-effective and practical option for labs looking to save on upfront costs and extend their cash runway. Leasing agreements at Excedr include maintenance and repair services, reducing the long-term burden of ownership, and access to a wide network of partners that offer a variety of services designed for biotech startups, middle-market biotechs, and large pharmaceuticals.

What Else Should I Consider When Purchasing an Ultra-Low Temperature Freezer?

After narrowing down the type of ULT freezer and manufacturer that fits your lab’s needs, it’s essential to think critically about the following factors:

  • Location and Orientation: Consider where the unit will be placed in your lab. Chest freezers require more floor space, while upright models need ample room to fully open their doors. If you suspect you’ll need to move the unit in the future, consider purchasing a freezer with casters for easier mobility.
  • Volume Capacity and Storage Options: Ensure the freezer has enough capacity to store your samples, and check how easily shelves, drawers, or boxes can be added for organization. Some units feature internal compartments with doors to improve accessibility and storage efficiency.
  • Energy Efficiency and Sustainability: Evaluate the freezer’s energy consumption. Does the freezer include features like temperature control or energy-saving modes? Is there a backup system for emergencies? Consider models with hydrocarbon refrigerants, which are more eco-friendly, and look for certifications like Energy Star for energy-efficient options.
  • Maintenance, Noise Levels, and Convenience: Routine maintenance is essential for long-term reliability. Look for freezers that are easy to service and operate quietly to avoid disruption in your lab. A strong warranty can also offer peace of mind in case of technical issues.

Standard Operating Procedures & Employee Safety

Integrating your new ULT freezer into your lab’s operational processes will require careful planning. Here are a few key considerations:

  • Standard Operating Procedures (SOPs): Ensure the freezer fits seamlessly into your lab’s workflow. You may need to adjust your existing SOPs to account for the freezer’s placement, temperature control settings, and access protocols.
  • Employee Safety: Given the extremely cold temperatures of ULT freezers, employees should only access them for short periods. Provide adequate protective gear and ensure that safety protocols are in place, especially if using walk-in freezers. Limiting access and time spent in these freezers can help prevent injury.

Making the Right Choice for Your Lab

With so many ultra-low temperature (ULT) freezers available on the market, it can be challenging to balance the needs of your laboratory with cost and value. It’s crucial to carefully evaluate the factors that matter most—such as price, energy efficiency, storage capacity, and location within your lab—before making a decision.

Leasing a ULT freezer can be a cost-effective alternative to purchasing outright. By leasing, you can save on upfront costs and maintenance expenses while still ensuring you have access to high-quality lab equipment. At Excedr, we provide leasing options that make it easier to acquire the equipment you need without the financial burden of ownership.

Whether you need long-term storage, short-term flexibility, or custom solutions, leasing offers the benefit of reduced risk and operational support. Get in touch today to explore our leasing program and find the perfect ultra-low temperature freezer for your lab’s needs.

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